NpgRJ_Nn_1822 32..39
نویسندگان
چکیده
KChIPs coassemble with pore-forming Kv4 a subunits to form a native complex in the brain and heart and regulate the expression and gating properties of Kv4 K1 channels, but the mechanisms underlying these processes are unknown. Here we report a co-crystal structure of the complex of human Kv4.3 N-terminus and KChIP1 at a 3.2-Å resolution. The structure reveals a unique clamping action of the complex, in which a single KChIP1 molecule, as a monomer, laterally clamps two neighboring Kv4.3 N-termini in a 4:4 manner, forming an octamer. The proximal N-terminal peptide of Kv4.3 is sequestered by its binding to an elongated groove on the surface of KChIP1, which is indispensable for the modulation of Kv4.3 by KChIP1, and the same KChIP1 molecule binds to an adjacent T1 domain to stabilize the tetrameric Kv4.3 channels. Taken together with biochemical and functional data, our findings provide a structural basis for the modulation of Kv4 by KChIPs.
منابع مشابه
Appropriate strategies for South Africa for the management of acute myocardial infarction in patients presenting with ST-segment elevation.
Introduction ...........................................29 The definition of acute myocardial infarction ...29 The pathogenesis of acute myocardial infarction ...........................................30 The natural history of acute myocardial infarction ...........................................30 Aims of management .................................31 Emergency care ............................
متن کاملCourse MA2C01, Michaelmas Term 2012 Section 3: Abstract Algebra
3 Abstract Algebra 32 3.1 Binary Operations on Sets . . . . . . . . . . . . . . . . . . . . 32 3.2 Commutative Binary Operations . . . . . . . . . . . . . . . . 32 3.3 Associative Binary Operations . . . . . . . . . . . . . . . . . . 32 3.4 Semigroups . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 3.5 The General Associative Law . . . . . . . . . . . . . . . . . . 34 3.6 Identity el...
متن کاملTask Force Report Management of acute myocardial infarction in patients presenting with ST-segment elevation The Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology,
Introduction ...........................................29 The definition of acute myocardial infarction ...29 The pathogenesis of acute myocardial infarction ...........................................30 The natural history of acute myocardial infarction ...........................................30 Aims of management .................................31 Emergency care ............................
متن کاملManagement of acute myocardial infarction in patients presenting with ST-segment elevation. The Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology.
Introduction ...........................................29 The definition of acute myocardial infarction ...29 The pathogenesis of acute myocardial infarction ...........................................30 The natural history of acute myocardial infarction ...........................................30 Aims of management .................................31 Emergency care ............................
متن کاملAntimalarial Drug Toxicity
26 1. Method and Search Strategy 28 2. Chloroquine 29 2.1 Mild and Moderate Adverse Effects 29 2.2 Severe Adverse Effects 30 2.3 Overdose Toxicity 30 2.4 Use in Pregnant Women 31 2.5 Use in Breast-Feeding Women 31 2.6 Contraindications and Cautions 31 3. Suifadoxine/Pyrimethamine 31 3.1 Miid and Moderate Adverse Effects 32 3.2 Severe Adverse Effects 32 3.2.1 Cutaneous Toxicity 32 3.2.2 Hepatic ...
متن کامل